BDBM10869 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide::CHEMBL6753::aromatic/heteroaromatic sulfonamide 14

SMILES Cn1nc(sc1=N)S(N)(=O)=O

InChI Key InChIKey=BWSMJWLWXNCHHP-UHFFFAOYSA-N

Data  112 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 10869   

TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  91.9nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  91.9nMAssay Description:Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Stylophora pistillata)
Centre Scientifique De Monaco

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  357nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Saccharomyces cerevisiae)
Balikesir University

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  360nMAssay Description:Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  393nMAssay Description:Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Sulfurihydrogenibium sp. (strain YO3AOP1))
Universit£

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  433nMAssay Description:Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Helicobacter pylori (strain G27))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  494nMAssay Description:Inhibition of Helicobacter pylori recombinant CAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Cryptococcus neoformans var. grubii (Filobasidiell...)
Universite Degli Studi Di Firenze

LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  815nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Candida albicans (Yeast))
Universite Degli Studi Di Firenze

LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  1.37E+3nM ΔG°:  -7.86kcal/molepH: 8.3 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Anopheles gambiae)
University Of Tampere And Tampere University Hospital

Curated by ChEMBL
LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  1.69E+3nMAssay Description:Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Mycobacterium tuberculosis)
Kochi Medical School

LigandPNGBDBM10869(5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-s...)
Affinity DataKi:  7.92E+3nM ΔG°:  -6.84kcal/molepH: 8.3 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed